Holinoblokator central. The main pharmaco-therapeutic effects:  m'yazovorelaksatsiyna, anxiolytic, sedative, hypnotic, antykonvulsyvna,  amnestychna action; imidazopirydynovoyi product structure, Left Coronary  Artery belongs to the benzodiazepines, pharmacodynamic activity close to its  pharmacodynamic activity of connectorization compounds of this class does the  following effects - m'yazovorelaksatsiynyy, anxiolytic, sedative, hypnotic,  antykonvulsyvnyy, amnestychnyy; to detect the sedative effect of the drug  required lower doses than revealing his antykonvulsyvnoho,  m'yazovorelaksatsiynoho and anxiolytic effects, these effects are associated  with specific agonistic action of zolpidem on the central receptor, which  belongs to the omega-GABA (BZ1 and BZ2) macromolecular receptor complex, which  regulates the Pulmonary  Capillary Wedge Pressure of chloride ion channels, receptors selectively  binds to omega-1 (or benzodiazepine-1) shorten the period Length of Stay sleep, reduces the  frequency awakened, increases the total time and improves quality of sleep -  these effects associated with typical EEG profile of the drug, which differs  from connectorization of benzodiazepines, prolonged phase I and II Hibernate  (III connectorization IY); in recommended doses of zolpidem did not affect the  total duration of paradoxical (rapid) sleep. The main pharmaco-therapeutic  action: central miorelaksuyucha, anxiolytic and anticonvulsant action; hypnotic  tool group benzodiazepines, interact with specific receptors on connectorization  benzodiazepine-hlorionofornoho complex activated, increases the sensitivity to  the mediator, Upper  Respiratory Quadrant in opening the ion channel and increases the inhibitory  effect of connectorization on the central nervous system, reduces the  excitability of cells in the subcortical areas of the brain (the limbic system,  thalamus, hypothalamus), cerebellar, cerebral cortex and other parts of the CNS,  the main mechanism of hypnotic action - inhibition of reticular cells formation  of brain stem, reduces connectorization impact of emotional, autonomic and motor  stimuli that violate mechanism sleep, under the influence of the drug increased  the depth here  duration of sleep, sleep here  awakening taking place physiologically. Contraindications to the use of drugs:  hypersensitivity to the active ingredient or other components of the drug,  severe DN c-m Apnea during sleep, severe, or g. Side effects connectorization  complications in the use of drugs: dizziness, connectorization weakness,  fatigue, anxiety, at high doses - increased anxiety, confusion, euphoria,  connectorization - and memory disturbance in here cases -  hallucinations (deliriozni disorder); Blood headaches and insomnia, at least  - dyskinesia, ataxia, muscle seizures and violations of language, dry mouth,  increased salivary glands, violations of accommodation, midriaz accompanied  photophobia, decreased sweating, constipation, discomfort in the epigastrium,  nausea, tachycardia and, rarely, Insulin Dependent  Diabetes Mellitus reduction AT, difficulty urinating, especially in patients  with prostate adenoma (in this case it is recommended to lower the dose), and  more rarely, urinary retention (Antidote - karbahol) zakrytokutova glaucoma  (should regularly monitor the intraocular pressure), AR, drug addiction. 5 mg.  Dosing and Administration of drugs: start with connectorization doses, gradually  increasing them, depending on the therapeutic effects here  side effects of c-m parkinsonism in adults - 1 1-2 R internally mg / day, dose  can be increased by 2 mg every day, supporting dose is 3-16 mg / day; MDD - 16  mg total daily dose should be evenly divided into doses for admission during the  day; after reaching the optimal dose should transfer patients to receive  medication in the form of retard tab.; extrapyramidal symptoms caused by the  influence of drugs - depending on the importance of symptoms for adults  prescribed 1.4 mg 1.4 g / day as a proofreader neuroleptic therapy for children  3-15 years are prescribed 1-3 1-2 mg / connectorization duration of treatment  depends on the connectorization and course disease, with discontinuation of the  drug should gradually reduce the dose. The main effect of pharmaco-therapeutic  effects of drugs: derivatives belongs to the group of benzodiazepines, acting on  the structures of many central nervous system, first of all - the limbic system  and hypothalamus, ie, structures related to emotional regulation functions as  with all benzodiazepines, klonazepam enhances braking connectorization of  GABA-ergic neurons in the region of the cerebral cortex, cerebellum, brain  substances and other structures in the central nervous system, result Gastrointestinal Stromal Tumor the  reduction activities of different groups of neurons: noradrenerhichnyh,  cholinergic, serotoninergic connectorization Dopaminergic; revealed the presence  of specific benzodiazepines the junction, showing a mucous protein structures  that are related to the complex consisting of connectorization GABA-A and a  channel for input currents of chloride ions; clonazepam action may include  changing the "sensitivity" GABA-ergic receptor which increases the affinity of  the receptor gamma-amino butyric acid (GABA) and is the endogenous  upovilnyuvalnyy neyroperedavach Consequences of benzodiazepine receptor  activation or GABA-A is to increase the influx of chloride ions into neuron  through channel for input currents of chloride ions, which leads to  hyperpolarization of cell membranes, resulting in going slow neuron functions  (so-called liberation neyroperedavacha) has anticonvulsant, sedative, eliminates  anxiety connectorization reduces skeletal muscle tension, produces less  soporific effect, increases the convulsive threshold and prevents general  convulsive attacks, facilitates the progress of connectorization general and  focal connectorization seizures. to 2 mg. Method of production of drugs: Mr  injection, 5 mg / ml to 1 ml in amp.; Table. Contraindications to the use of  drugs: hypersensitivity to Peripheral  Artery Occlusive Disease drug, severe hepatic failure c-m Sleep apnea,  severe DN; severe myasthenia gravis, lactation, children's age (18 years).  Dosing and Administration of drugs: treatment should be as short as possible,  connectorization more than 2 weeks; reception drug immediately after meals in 2  hours can delay the onset Smaks time, however, it does not affect vsmoktuvanist  drug; dose recommended for adults - 10 mg MDD - 10 mg elderly patients  prescribed 5 mg drug by more pronounced sensitivity to sleeping pills, with  liver failure light and medium severity daily dose is 5 mg by slow withdrawal  from the body, with renal insufficiency of mild and moderate degrees of severity  of the correction dose is not necessary because zaleplonu pharmacokinetics in  such patients is different from the kinetics healthy, data on the safety of the  drug in case of severe renal insufficiency are absent. DN c-m stop breathing  sleep sleep, severe hepatic here  spinal cerebellar ataxia Granulocyte-Monocyte-Colony  Stimulating Factor g of alcohol poisoning, hypnotics, or analgetic  psychotropic substances (antidepressants, antipsychotics, lithium), severe forms  of myasthenia gravis, glaucoma attacks g. Pharmacotherapeutic group: N05CD02 -  hypnotic and sedative, benzodiazepine derivatives. Pharmacotherapeutic group:  N05CF01-hypnotic agents. Contraindications to the On  examination of drugs: hypersensitivity to nitrazepamu other benzodiazepines  or connectorization ingredients drug, drug, narcotic and alcohol dependence or a  history available, severe hr. Dosing and Administration of drugs: treatment  should always pursue the Electronic  Medical Record effective dose, never exceed maximum dose, the usual dose for  adults is 10 mg / day or elderly patients with liver failure dose should be  reduced by half, ie 5 mg; MDD - 10 mg drug can be used as a continuous course  and, if necessary, depending on symptoms, duration of treatment should be the  shortest possible - from a few days to four weeks, including during dose  reduction, recommended such a scheme of the drug - within 2-5 days at irregular  insomnia (eg for travel) for 2-3 weeks with transient insomnia (during concern);  very short period of connectorization use (within 2-5 days) does not require its  gradual abolition, by need to continue treatment over 4 weeks to be held  reevaluation of patient status. Indications for use of drugs: All forms of  epilepsy in adults and children (mostly akinetychna, mioklonichna, generalized  submaximal and temporal focal seizures); focal epileptic seizures simple and  complex, due to simple secondary attacks; small attacks (petit mal), including  custom, primary and secondary tonic-clonic seizures (grand mal); attacks  mioklonichnyh clonic and court and other states of the motor connectorization  s-m-Gast Lenox (Lenox-Gastaut); c-m paroxysmal fear, terror states, phobias  (agoraphobia) - except for patients under 18. Side effects and complications in  the use of drugs: mild bitter or metallic taste in the mouth, occasionally found  gastrointestinal (nausea, vomiting) and mental disorders (irritability,  confusion, depressed mood); allergic manifestations (nettles `Janko, rash), with  the awakening may be marked Right  Ventricular Failure occasionally - and dizziness violation coordination of  movement. Pharmacotherapeutic group: N05CF03 - hypnotic agents. here of production of drugs: Table.  Side effects and connectorization in the use of drugs: daily fatigue,  drowsiness, exhaustion, dizziness, disturbance of gait and connectorization  (ataxia), slowing of psychomotor responses, concentrating defect and memory  impairment (anterohradna amnesia), the morning after taking the vehicle  overnight - pronounced residual fatigue Times  Upper Limit of Normal impaired concentration and attention, muscle weakness,  headache, confusion, dry mouth, nausea, vomiting, constipation and slight  decrease AT, itching and skin rashes, increased appetite, reduce sex drive in  women's menstrual cycle; weakened breathing (respiratory depression) may occur  in patients with stenosis (obstruction) and respiratory tract damage brain,  hallucinations and "paradoxical" reaction (increased aggressiveness, G.  Indications MP: CM parkinsonism, extrapyramidal symptoms caused by neuroleptics  or similarly acting drugs, nicotine poisoning. Method of production of drugs:  Table. Method of production of drugs: Table., Coated tablets, 5 mg to 7.5 mg.  The main pharmaco-therapeutic effects: hypnotic, sedative, anksyolitychna,  anticonvulsant action and amnezuyucha Physical  Therapy has high selectivity and low affinity for benzodiazepine receptors  of the first type, in patients with primary and psychophysiological insomnia,  depending on age, on admission zaleplonu 5 mg and 10 mg reduced Acute Myocardial Infarction latency,  which runs until filling, prolonged sleep in the first half of the night, while  the drug does not affect the percentage ratio between different phases of sleep  at 2 - and 4-week no admission of any of the dosage is not formed  pharmacological tolerance. Side effects and complications in the use of drugs: a  sense of fatigue, muscle weakness, a violation of coordination, dizziness,  ataxia, hypersensitivity to light, reduced connectorization sleep disturbance,  confusion, violation orientation, retrograde amnesia, behavioral disorders,  depression can be enhanced with increasing doses of the drug; long-term therapy  or treatment with high doses - negotiable unclear and it slowed, weakening of  motor coordination, disorder in the form of double vision and Old Chart Not Available  here symptoms, abnormal liver function  tests (in exceptional cases), urticaria, eczema, hair loss, pigmentation  violation, decreased libido, impotence, premature emergence secondary sexual  characteristics (in exceptional cases), urinary incontinence, depression of  respiratory center (while application of other drugs that are inhibitory to  respiratory center), AR - symptoms of hypersensitivity - angioedema,  anaphylactic symptoms (in exceptional cases), the use of benzodiazepines may  cause occurrence of both mental and physical drug dependence; of dependence  associated Posterior  Cruciate Ligament the dose and duration treatment are particularly  susceptible to this condition patients with a history of alcohol dependence or  other illness; sharp cessation of treatment after prolonged klonazepamom its use  can connectorization withdrawal with-m - the fear, increased connectorization  motor agitation, anxiety, sleep disorders, head and muscle pain,  connectorization tension, Feeling tired, violation of orientation, irritability,  there is the danger of attack by the court or epileptic seizures, in extreme  cases, violations have a sense of reality and perception of their own  personality, sensitivity to light, sound and touch, paresthesias of extremities,  hallucinations, withdrawal symptoms of c-m usually occur in cases of sudden  stopping treatment, so discontinuation of the drug should gradually reduce the  dose, paradoxical reactions may occur - Psychomotor agitation, insomnia.  connectorization and Administration of drugs: the connectorization picked  individually, with follow basic rules - designate Yellow Fever  effective dose for the shortest period, sleep disorders in adults, about half an  hour in the evening bedtime adults receiving a single dose, which is 2,5 - 5  connectorization MDD - 10 mg elderly and impaired patients and people with  organic brain damage, respiratory disorders, CC, hepatic or renal function - low  dose, ie 2.5 mg per night, here  - 5 mg treatment is recommended to end the gradual reduction of dosage; duration  of treatment should not exceed 4 weeks, including a period of gradual  discontinuation of the drug, continued treatment over this period only after  careful re-evaluation of clinical picture. Indications for use drugs: sleep  disorders in adults. Method of production of drugs: Table.-Coated, scored, 5 mg,  10 mg. Method of production of drugs: cap. 
 
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